Protocol for the development of the international population registry for aphasia after stroke (I-PRAISE)

Background We require high-quality information on the current burden, types of therapy and resources available, methods delivery, care pathways long-term outcomes for people with aphasia.Aim To document inform international delivery post-stroke aphasia treatment, to optimise recovery reintegration aphasia.Methods & Procedures Multi-centre, prospective, non-randomised, open study, employing blinded outcome assessment, where appropriate, including aphasia, able attend 30 minutes during initial language at first contact a speech therapist assessment participating sites. There is no study-mandated intervention. Assessments will occur baseline (first assessment), discharge from Speech Language Therapy (SLT), 6 12-months post-stroke. Our primary changed in Amsterdam Nijmegen Everyday Test (ANELT/Scenario participants severe verbal impairments) Secondary 12 months include Outcome Measure (TOMS), Subjective Index Physical Social (SIPSO), Aphasia Severity Rating Scale (ASRS), Western Battery Quotient (WAB-AQ), stroke quality life scale (SAQoL-39), European Quality Life (EQ-5D), lesion description, General Health Questionnaire (GHQ-12), resource use, satisfaction provision success. collect demography, clinical data, content. Routine neuroimaging medication administration records be accessed possible; imaging pseudonymised transferred central reading centre. Data collected registry. describe profiles therapies available. International individual participant data (IPD) meta-analyses examine treatment responder rates based minimal detectable change clinically important changes secondary months. Multivariable associations between therapy, use outcomes, considering service characteristics. Where feasible, costs associated reported. we detail brain size site, correlations SLT months.Conclusion differences care, utilisation highlight avenues further research, promote knowledge sharing rehabilitation delivery. IPD enhance expand understanding, identifying cost-effective promising approaches benefit aphasia.